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| Moraes de Carvalho,Katharinne I; Fernandes,Hélio B; Frota Machado,Flávia D; Oliveira,Irisdalva S; Oliveira,Francisco A; Nunes,Paulo Humberto M; Lima,Julianeli T; Silva Almeida,Jackson R G; Meneses Oliveira,Rita C. |
| This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective... |
| Tipo: Journal article |
Palavras-chave: Antioxidant; Antiulcer activity; Encholirium spectabile; Bromeliaceae. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400011 |
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